TREATMENT OF IRRITANT CONTACT DERMATITIS:
AN IN VIVO STUDY
March 20, 1998

Prepared by:
Nancy A. Monteiro-Riviere, Ph.D.
Professor of Investigative Dermatology
Cutaneous Pharmacology and Toxicology Center
North Carolina State University
Raleigh, North Carolina

The following is a summary of the trial conducted at NCSU to evaluate the effects of Protèque treatment of sodium lauryl sulfate (SLS) induced skin irritation:

This study consisted of four pigs with nine treatment sites on each pig. Treatment sites included control, 1% SLS, Protèque alone and six treatments assessing the effects of Protèque pre-SLS, post-SLS, and use of the cleanser before Protèque application. Observations were taken at 24 and 48 hours using a standard Draize erythema score and transepidermal water loss (TEWL) as endpoints.

Application of Protèque (or cleanser followed by Protèque) after SLS treatment completely eliminated the erythema seen with SLS. This study concluded that application of Protèque after exposure to 1 % SLS completely eliminated the irritation as assessed by erythema. This protection persisted for 48 hours.

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